Indianapolis Colts vs San Francisco 49ers: Prediction, Head-to-Head, Odds & Stats (Tue, 23 Dec '25)

Wojtek Kolan

Wojtek Kolan

Published on 23 Dec, 01:15 AM UTC

Next Match 23/12/25 at 01:15 AM

Indianapolis Colts vs San Francisco 49ers
📍 Lucas Oil Stadium, USA.

Scheduled H2H Match For Indianapolis Colts Vs San Francisco 49ers

NFL

Tue, 23 Dec 2025 at 01:15 AM UTC

Indianapolis Colts
Indianapolis Colts

USA USA

Recent Form

W
W
W
L
W
San Francisco 49ers
San Francisco 49ers

USA USA

Recent Form

W
L
W
L
W

3

Win

Last 4 Played

4
0 Draws

1

Win

5
Position
10
Shane Steichen
Manager
Kyle Shanahan

Game Schedule - Time Of Fixture

Indianapolis Colts will square off vs San Francisco 49ers in NFL on Tue, 23 Dec 2025 at 01:15 AM UTC. Let’s investigate historical performances, recent stats and head-2-head information to find out the most accurate picks and best bets.

Indianapolis Colts vs San Francisco 49ers H2H Match Summary

In the last 4 H2H games for these competitors, Indianapolis Colts have got the victory 3 times and San Francisco 49ers have got the victory on 1 occasion. In the most recent fixture between them, Indianapolis Colts won 18-30.


Head-to-Head (Last 4 Matches)
Indianapolis Colts3
San Francisco 49ers1

Indianapolis Colts vs San Francisco 49ers Past H2H Matches

9464
NFL
12:20 AM
25/10/21
San Francisco 49ers
18
Indianapolis Colts
30
05:00 PM
08/10/17
Indianapolis Colts
26
San Francisco 49ers
23
06:00 PM
25/11/01
Indianapolis Colts
21
San Francisco 49ers
40
9465
NFL Preseason
08:30 PM
25/08/18
Indianapolis Colts
23
San Francisco 49ers
17

Indianapolis Colts Recent Matches

9464
NFL (27 Matches)
02:30 PM
09/11/25
Indianapolis Colts
31
Atlanta Falcons
25
W
06:00 PM
02/11/25
Pittsburgh Steelers
27
Indianapolis Colts
20
L
08:25 PM
26/10/25
Indianapolis Colts
38
Tennessee Titans
14
W
08:05 PM
19/10/25
Los Angeles Chargers
24
Indianapolis Colts
38
W
05:00 PM
12/10/25
Indianapolis Colts
31
Arizona Cardinals
27
W
05:00 PM
05/10/25
Indianapolis Colts
40
Las Vegas Raiders
6
W
08:05 PM
28/09/25
Los Angeles Rams
27
Indianapolis Colts
20
L
05:00 PM
21/09/25
Tennessee Titans
20
Indianapolis Colts
41
W
08:05 PM
14/09/25
Indianapolis Colts
29
Denver Broncos
28
W
05:00 PM
07/09/25
Indianapolis Colts
33
Miami Dolphins
8
W
06:00 PM
05/01/25
Indianapolis Colts
26
Jacksonville Jaguars
23
W
06:00 PM
29/12/24
New York Giants
45
Indianapolis Colts
33
L
06:00 PM
22/12/24
Indianapolis Colts
38
Tennessee Titans
30
W
09:25 PM
15/12/24
Denver Broncos
31
Indianapolis Colts
13
L
06:00 PM
01/12/24
New England Patriots
24
Indianapolis Colts
25
W
06:00 PM
24/11/24
Indianapolis Colts
6
Detroit Lions
24
L
06:00 PM
17/11/24
New York Jets
27
Indianapolis Colts
28
W
06:00 PM
10/11/24
Indianapolis Colts
20
Buffalo Bills
30
L
01:20 AM
04/11/24
Minnesota Vikings
21
Indianapolis Colts
13
L
05:00 PM
27/10/24
Houston Texans
23
Indianapolis Colts
20
L
05:00 PM
20/10/24
Indianapolis Colts
16
Miami Dolphins
10
W
05:00 PM
13/10/24
Tennessee Titans
17
Indianapolis Colts
20
W
05:00 PM
06/10/24
Jacksonville Jaguars
37
Indianapolis Colts
34
L
05:00 PM
29/09/24
Indianapolis Colts
27
Pittsburgh Steelers
24
W
05:00 PM
22/09/24
Indianapolis Colts
21
Chicago Bears
16
W
05:00 PM
15/09/24
Green Bay Packers
16
Indianapolis Colts
10
L
05:00 PM
08/09/24
Indianapolis Colts
27
Houston Texans
29
L
9465
NFL Preseason (3 Matches)
05:00 PM
23/08/25
Cincinnati Bengals
14
Indianapolis Colts
41
W
05:00 PM
16/08/25
Indianapolis Colts
19
Green Bay Packers
23
L
11:00 PM
07/08/25
Baltimore Ravens
24
Indianapolis Colts
16
L

San Francisco 49ers Recent Matches

9464
NFL (27 Matches)
09:05 PM
16/11/25
Arizona Cardinals
22
San Francisco 49ers
41
W
09:25 PM
09/11/25
San Francisco 49ers
26
Los Angeles Rams
42
L
06:00 PM
02/11/25
New York Giants
24
San Francisco 49ers
34
W
05:00 PM
26/10/25
Houston Texans
26
San Francisco 49ers
15
L
12:20 AM
20/10/25
San Francisco 49ers
20
Atlanta Falcons
10
W
08:25 PM
12/10/25
Tampa Bay Buccaneers
30
San Francisco 49ers
19
L
12:15 AM
03/10/25
Los Angeles Rams
23
San Francisco 49ers
26
W
08:05 PM
28/09/25
San Francisco 49ers
21
Jacksonville Jaguars
26
L
08:25 PM
21/09/25
San Francisco 49ers
16
Arizona Cardinals
15
W
05:00 PM
14/09/25
New Orleans Saints
21
San Francisco 49ers
26
W
08:05 PM
07/09/25
Seattle Seahawks
13
San Francisco 49ers
17
W
09:25 PM
05/01/25
Arizona Cardinals
47
San Francisco 49ers
24
L
01:15 AM
31/12/24
San Francisco 49ers
34
Detroit Lions
40
L
09:25 PM
22/12/24
Miami Dolphins
29
San Francisco 49ers
17
L
01:15 AM
13/12/24
San Francisco 49ers
6
Los Angeles Rams
12
L
09:25 PM
08/12/24
San Francisco 49ers
38
Chicago Bears
13
W
01:20 AM
02/12/24
Buffalo Bills
35
San Francisco 49ers
10
L
09:25 PM
24/11/24
Green Bay Packers
38
San Francisco 49ers
10
L
09:05 PM
17/11/24
San Francisco 49ers
17
Seattle Seahawks
20
L
06:00 PM
10/11/24
Tampa Bay Buccaneers
20
San Francisco 49ers
23
W
12:20 AM
28/10/24
San Francisco 49ers
30
Dallas Cowboys
24
W
08:25 PM
20/10/24
San Francisco 49ers
18
Kansas City Chiefs
28
L
12:15 AM
11/10/24
Seattle Seahawks
24
San Francisco 49ers
36
W
08:05 PM
06/10/24
San Francisco 49ers
23
Arizona Cardinals
24
L
08:05 PM
29/09/24
San Francisco 49ers
30
New England Patriots
13
W
08:25 PM
22/09/24
Los Angeles Rams
27
San Francisco 49ers
24
L
05:00 PM
15/09/24
Minnesota Vikings
23
San Francisco 49ers
17
L
9465
NFL Preseason (3 Matches)
12:30 AM
24/08/25
San Francisco 49ers
30
Los Angeles Chargers
23
W
08:00 PM
16/08/25
Las Vegas Raiders
19
San Francisco 49ers
22
W
12:30 AM
10/08/25
San Francisco 49ers
9
Denver Broncos
30
L

Indianapolis Colts Next Fixtures

San Francisco 49ers Next Fixtures

Indianapolis Colts Last Match Played stats

Indianapolis Colts vs Atlanta Falcons

Final Score :31 - 25

(H)Offense (A)
4Touchdowns3
2/3Field goals1/1
519Total yards290
2Turnovers1
2/4Red zone efficiency3/3
40:20Time of Possession26:09
25First downs22
2First downs by penalty0
2/12 (16%)Third down efficiency0/8 (0%)
1Punts6
44Average yards per punt43.8
7Average yards per play4.8
(H)Passing (A)
10First downs by passing10
196Net yards passing150
255Gross yards passing177
1Passing touchdowns1
1Interceptions thrown0
5.9Average passing yards per attempt4.8
0Red zone passing attempts1
(H)Rushing (A)
41Rushing attempts29
323Rushing yards140
7.9Average rushing yards per attempt4.8
15First downs by rushing10
11Red zone rushing attempts5
(H)Other (A)
7Penalties3
56Yards penalized35
4Fumbles1
1Fumbles lost1

San Francisco 49ers Last Match Played stats

Arizona Cardinals vs San Francisco 49ers

Final Score :22 - 41

(H)Offense (A)
3Touchdowns5
1/2Field goals3/3
488Total yards281
3Turnovers0
3/5Red zone efficiency4/5
34:15Time of Possession25:45
24First downs24
3First downs by penalty1
6/14 (42%)Third down efficiency3/9 (33%)
3Punts3
40.7Average yards per punt46.3
6.9Average yards per play5.4
(H)Passing (A)
18First downs by passing13
452Net yards passing186
452Gross yards passing200
2Passing touchdowns3
2Interceptions thrown0
7.9Average passing yards per attempt6.9
10Red zone passing attempts6
(H)Rushing (A)
14Rushing attempts25
36Rushing yards95
2.6Average rushing yards per attempt3.8
5First downs by rushing8
4Red zone rushing attempts4
(H)Other (A)
17Penalties1
130Yards penalized15
1Fumbles0
1Fumbles lost0

NFL 25/26 Standings

POSTEAMMPWLDPTS
1Denver Broncos119200.818
2New England Patriots119200.818
3Philadelphia Eagles108200.8
4Los Angeles Rams108200.8
5Indianapolis Colts108200.8
6Buffalo Bills107300.7
7Seattle Seahawks107300.7
8Chicago Bears107300.7
9Green Bay Packers106310.65
10San Francisco 49ers117400.636
11Los Angeles Chargers117400.636
12Jacksonville Jaguars106400.6
13Pittsburgh Steelers106400.6
14Detroit Lions106400.6
15Tampa Bay Buccaneers106400.6
16Carolina Panthers116500.545
17Houston Texans105500.5
18Baltimore Ravens105500.5
19Kansas City Chiefs105500.5
20Dallas Cowboys104510.45
21Minnesota Vikings104600.4
22Miami Dolphins114700.364
23Cincinnati Bengals103700.3
24Atlanta Falcons103700.3
25Arizona Cardinals103700.3
26Washington Commanders113800.273
27Cleveland Browns102800.2
28Las Vegas Raiders102800.2
29New Orleans Saints102800.2
30New York Jets102800.2
31New York Giants112900.182
32Tennessee Titans101900.1