Indianapolis Colts vs San Francisco 49ers: Prediction, Head-to-Head, Odds & Stats (Tue, 23 Dec '25)
Wojtek Kolan
Published on 23 Dec, 01:15 AM UTC
Next Match 23/12/25 at 01:15 AM
Indianapolis Colts vs San Francisco 49ers
📍 Lucas Oil Stadium, USA.
Scheduled H2H Match For Indianapolis Colts Vs San Francisco 49ers
NFL
Tue, 23 Dec 2025 at 01:15 AM UTC
Indianapolis Colts
USA
Recent Form
L
W
W
W
W
3
Win
Last 4 Played
4
0 Draws1
Win
1
Position
12
Shane Steichen
Manager
Kyle Shanahan
San Francisco 49ers
USA
Recent Form
L
W
L
W
L
3
Win
Last 4 Played
4
0 Draws1
Win
1
Position
12
Shane Steichen
Manager
Kyle Shanahan
Game Schedule - Time Of Fixture
Indianapolis Colts will square off vs San Francisco 49ers in NFL on Tue, 23 Dec 2025 at 01:15 AM UTC. Let’s investigate historical performances, recent stats and head-2-head information to find out the most accurate picks and best bets.
Indianapolis Colts vs San Francisco 49ers H2H Game Summary
For the last 4 head-2-head games between these competitors, Indianapolis Colts have come out on top 3 times and San Francisco 49ers have come out on top on 1 occasion. In the latest game between them, Indianapolis Colts won 18-30.
| Head-to-Head (Last 4 Matches) | |
|---|---|
| Indianapolis Colts | 3 |
| San Francisco 49ers | 1 |
Indianapolis Colts vs San Francisco 49ers Past H2H Matches
NFL
12:20 AM
25/10/21
25/10/21
San Francisco 49ers
18
Indianapolis Colts
30
05:00 PM
08/10/17
08/10/17
Indianapolis Colts
26
San Francisco 49ers
23
06:00 PM
25/11/01
25/11/01
Indianapolis Colts
21
San Francisco 49ers
40
NFL Preseason
08:30 PM
25/08/18
25/08/18
Indianapolis Colts
23
San Francisco 49ers
17
Indianapolis Colts Recent Matches
NFL (26 Matches)
06:00 PM
02/11/25
02/11/25
Pittsburgh Steelers
27
Indianapolis Colts
20
L
08:25 PM
26/10/25
26/10/25
Indianapolis Colts
38
Tennessee Titans
14
W
08:05 PM
19/10/25
19/10/25
Los Angeles Chargers
24
Indianapolis Colts
38
W
05:00 PM
12/10/25
12/10/25
Indianapolis Colts
31
Arizona Cardinals
27
W
05:00 PM
05/10/25
05/10/25
Indianapolis Colts
40
Las Vegas Raiders
6
W
08:05 PM
28/09/25
28/09/25
Los Angeles Rams
27
Indianapolis Colts
20
L
05:00 PM
21/09/25
21/09/25
Tennessee Titans
20
Indianapolis Colts
41
W
08:05 PM
14/09/25
14/09/25
Indianapolis Colts
29
Denver Broncos
28
W
05:00 PM
07/09/25
07/09/25
Indianapolis Colts
33
Miami Dolphins
8
W
06:00 PM
05/01/25
05/01/25
Indianapolis Colts
26
Jacksonville Jaguars
23
W
06:00 PM
29/12/24
29/12/24
New York Giants
45
Indianapolis Colts
33
L
06:00 PM
22/12/24
22/12/24
Indianapolis Colts
38
Tennessee Titans
30
W
09:25 PM
15/12/24
15/12/24
Denver Broncos
31
Indianapolis Colts
13
L
06:00 PM
01/12/24
01/12/24
New England Patriots
24
Indianapolis Colts
25
W
06:00 PM
24/11/24
24/11/24
Indianapolis Colts
6
Detroit Lions
24
L
06:00 PM
17/11/24
17/11/24
New York Jets
27
Indianapolis Colts
28
W
06:00 PM
10/11/24
10/11/24
Indianapolis Colts
20
Buffalo Bills
30
L
01:20 AM
04/11/24
04/11/24
Minnesota Vikings
21
Indianapolis Colts
13
L
05:00 PM
27/10/24
27/10/24
Houston Texans
23
Indianapolis Colts
20
L
05:00 PM
20/10/24
20/10/24
Indianapolis Colts
16
Miami Dolphins
10
W
05:00 PM
13/10/24
13/10/24
Tennessee Titans
17
Indianapolis Colts
20
W
05:00 PM
06/10/24
06/10/24
Jacksonville Jaguars
37
Indianapolis Colts
34
L
05:00 PM
29/09/24
29/09/24
Indianapolis Colts
27
Pittsburgh Steelers
24
W
05:00 PM
22/09/24
22/09/24
Indianapolis Colts
21
Chicago Bears
16
W
05:00 PM
15/09/24
15/09/24
Green Bay Packers
16
Indianapolis Colts
10
L
05:00 PM
08/09/24
08/09/24
Indianapolis Colts
27
Houston Texans
29
L
NFL Preseason (4 Matches)
05:00 PM
23/08/25
23/08/25
Cincinnati Bengals
14
Indianapolis Colts
41
W
05:00 PM
16/08/25
16/08/25
Indianapolis Colts
19
Green Bay Packers
23
L
11:00 PM
07/08/25
07/08/25
Baltimore Ravens
24
Indianapolis Colts
16
L
12:00 AM
23/08/24
23/08/24
Cincinnati Bengals
14
Indianapolis Colts
27
W
San Francisco 49ers Recent Matches
NFL (26 Matches)
06:00 PM
02/11/25
02/11/25
New York Giants
24
San Francisco 49ers
34
W
05:00 PM
26/10/25
26/10/25
Houston Texans
26
San Francisco 49ers
15
L
12:20 AM
20/10/25
20/10/25
San Francisco 49ers
20
Atlanta Falcons
10
W
08:25 PM
12/10/25
12/10/25
Tampa Bay Buccaneers
30
San Francisco 49ers
19
L
12:15 AM
03/10/25
03/10/25
Los Angeles Rams
23
San Francisco 49ers
26
W
08:05 PM
28/09/25
28/09/25
San Francisco 49ers
21
Jacksonville Jaguars
26
L
08:25 PM
21/09/25
21/09/25
San Francisco 49ers
16
Arizona Cardinals
15
W
05:00 PM
14/09/25
14/09/25
New Orleans Saints
21
San Francisco 49ers
26
W
08:05 PM
07/09/25
07/09/25
Seattle Seahawks
13
San Francisco 49ers
17
W
09:25 PM
05/01/25
05/01/25
Arizona Cardinals
47
San Francisco 49ers
24
L
01:15 AM
31/12/24
31/12/24
San Francisco 49ers
34
Detroit Lions
40
L
09:25 PM
22/12/24
22/12/24
Miami Dolphins
29
San Francisco 49ers
17
L
01:15 AM
13/12/24
13/12/24
San Francisco 49ers
6
Los Angeles Rams
12
L
09:25 PM
08/12/24
08/12/24
San Francisco 49ers
38
Chicago Bears
13
W
01:20 AM
02/12/24
02/12/24
Buffalo Bills
35
San Francisco 49ers
10
L
09:25 PM
24/11/24
24/11/24
Green Bay Packers
38
San Francisco 49ers
10
L
09:05 PM
17/11/24
17/11/24
San Francisco 49ers
17
Seattle Seahawks
20
L
06:00 PM
10/11/24
10/11/24
Tampa Bay Buccaneers
20
San Francisco 49ers
23
W
12:20 AM
28/10/24
28/10/24
San Francisco 49ers
30
Dallas Cowboys
24
W
08:25 PM
20/10/24
20/10/24
San Francisco 49ers
18
Kansas City Chiefs
28
L
12:15 AM
11/10/24
11/10/24
Seattle Seahawks
24
San Francisco 49ers
36
W
08:05 PM
06/10/24
06/10/24
San Francisco 49ers
23
Arizona Cardinals
24
L
08:05 PM
29/09/24
29/09/24
San Francisco 49ers
30
New England Patriots
13
W
08:25 PM
22/09/24
22/09/24
Los Angeles Rams
27
San Francisco 49ers
24
L
05:00 PM
15/09/24
15/09/24
Minnesota Vikings
23
San Francisco 49ers
17
L
12:15 AM
10/09/24
10/09/24
San Francisco 49ers
32
New York Jets
19
W
NFL Preseason (4 Matches)
12:30 AM
24/08/25
24/08/25
San Francisco 49ers
30
Los Angeles Chargers
23
W
08:00 PM
16/08/25
16/08/25
Las Vegas Raiders
19
San Francisco 49ers
22
W
12:30 AM
10/08/25
10/08/25
San Francisco 49ers
9
Denver Broncos
30
L
02:00 AM
24/08/24
24/08/24
Las Vegas Raiders
24
San Francisco 49ers
24
D
Indianapolis Colts Next Fixtures
NFL
02:30 PM
09/11/25
09/11/25
Indianapolis Colts
Atlanta Falcons
Prediction
06:00 PM
23/11/25
23/11/25
Kansas City Chiefs
Indianapolis Colts
Prediction
06:00 PM
30/11/25
30/11/25
Indianapolis Colts
Houston Texans
Prediction
06:00 PM
07/12/25
07/12/25
Jacksonville Jaguars
Indianapolis Colts
Prediction
09:25 PM
14/12/25
14/12/25
Seattle Seahawks
Indianapolis Colts
Prediction
01:15 AM
23/12/25
23/12/25
Indianapolis Colts
San Francisco 49ers
Prediction
06:00 PM
28/12/25
28/12/25
Indianapolis Colts
Jacksonville Jaguars
Prediction
06:00 PM
04/01/26
04/01/26
Houston Texans
Indianapolis Colts
Prediction
San Francisco 49ers Next Fixtures
NFL
09:25 PM
09/11/25
09/11/25
San Francisco 49ers
Los Angeles Rams
Prediction
09:05 PM
16/11/25
16/11/25
Arizona Cardinals
San Francisco 49ers
Prediction
01:15 AM
25/11/25
25/11/25
San Francisco 49ers
Carolina Panthers
Prediction
06:00 PM
30/11/25
30/11/25
Cleveland Browns
San Francisco 49ers
Prediction
09:25 PM
14/12/25
14/12/25
San Francisco 49ers
Tennessee Titans
Prediction
01:15 AM
23/12/25
23/12/25
Indianapolis Colts
San Francisco 49ers
Prediction
01:20 AM
29/12/25
29/12/25
San Francisco 49ers
Chicago Bears
Prediction
06:00 PM
04/01/26
04/01/26
San Francisco 49ers
Seattle Seahawks
Prediction
Indianapolis Colts Last Match Played stats
Pittsburgh Steelers vs Indianapolis Colts
Final Score :27 - 20
| (H) | Offense | (A) |
|---|---|---|
| 3 | Touchdowns | 2 |
| 2/2 | Field goals | 2/2 |
| 225 | Total yards | 368 |
| 1 | Turnovers | 6 |
| 3/6 | Red zone efficiency | 2/2 |
| 28:05 | Time of Possession | 31:55 |
| 17 | First downs | 26 |
| 3 | First downs by penalty | 2 |
| 4/12 (33%) | Third down efficiency | 6/14 (42%) |
| 5 | Punts | 2 |
| 50.4 | Average yards per punt | 55 |
| 3.7 | Average yards per play | 5 |
| (H) | Passing | (A) |
| 10 | First downs by passing | 17 |
| 187 | Net yards passing | 313 |
| 203 | Gross yards passing | 342 |
| 1 | Passing touchdowns | 1 |
| 0 | Interceptions thrown | 3 |
| 4.9 | Average passing yards per attempt | 5.7 |
| 9 | Red zone passing attempts | 7 |
| (H) | Rushing | (A) |
| 23 | Rushing attempts | 19 |
| 38 | Rushing yards | 55 |
| 1.7 | Average rushing yards per attempt | 2.9 |
| 5 | First downs by rushing | 6 |
| 7 | Red zone rushing attempts | 3 |
| (H) | Other | (A) |
| 8 | Penalties | 5 |
| 46 | Yards penalized | 53 |
| 1 | Fumbles | 4 |
| 1 | Fumbles lost | 3 |
San Francisco 49ers Last Match Played stats
New York Giants vs San Francisco 49ers
Final Score :24 - 34
| (H) | Offense | (A) |
|---|---|---|
| 3 | Touchdowns | 4 |
| 1/2 | Field goals | 2/2 |
| 296 | Total yards | 380 |
| 0 | Turnovers | 1 |
| 2/3 | Red zone efficiency | 4/5 |
| 26:49 | Time of Possession | 33:11 |
| 19 | First downs | 25 |
| 2 | First downs by penalty | 2 |
| 5/12 (41%) | Third down efficiency | 6/11 (54%) |
| 5 | Punts | 2 |
| 46.6 | Average yards per punt | 43.5 |
| 5.3 | Average yards per play | 5.8 |
| (H) | Passing | (A) |
| 7 | First downs by passing | 13 |
| 179 | Net yards passing | 221 |
| 191 | Gross yards passing | 235 |
| 2 | Passing touchdowns | 2 |
| 0 | Interceptions thrown | 0 |
| 5.1 | Average passing yards per attempt | 8.5 |
| 3 | Red zone passing attempts | 6 |
| (H) | Rushing | (A) |
| 21 | Rushing attempts | 39 |
| 117 | Rushing yards | 159 |
| 5.6 | Average rushing yards per attempt | 4.1 |
| 10 | First downs by rushing | 10 |
| 3 | Red zone rushing attempts | 7 |
| (H) | Other | (A) |
| 5 | Penalties | 6 |
| 23 | Yards penalized | 34 |
| 0 | Fumbles | 1 |
| 0 | Fumbles lost | 1 |
NFL 25/26 Standings
| POS | TEAM | MP | W | L | D | PTS |
|---|---|---|---|---|---|---|
| 1 | 9 | 7 | 2 | 0 | 0.778 | |
| 2 | 9 | 7 | 2 | 0 | 0.778 | |
| 3 | 9 | 7 | 2 | 0 | 0.778 | |
| 4 | 8 | 6 | 2 | 0 | 0.75 | |
| 5 | 8 | 6 | 2 | 0 | 0.75 | |
| 6 | 8 | 6 | 2 | 0 | 0.75 | |
| 7 | 8 | 6 | 2 | 0 | 0.75 | |
| 8 | 8 | 6 | 2 | 0 | 0.75 | |
| 9 | 8 | 5 | 2 | 1 | 0.688 | |
| 10 | 9 | 6 | 3 | 0 | 0.667 | |
| 11 | 9 | 6 | 3 | 0 | 0.667 | |
| 12 | 8 | 5 | 3 | 0 | 0.625 | |
| 13 | 8 | 5 | 3 | 0 | 0.625 | |
| 14 | 8 | 5 | 3 | 0 | 0.625 | |
| 15 | 8 | 5 | 3 | 0 | 0.625 | |
| 16 | 9 | 5 | 4 | 0 | 0.556 | |
| 17 | 9 | 5 | 4 | 0 | 0.556 | |
| 18 | 8 | 4 | 4 | 0 | 0.5 | |
| 19 | 8 | 3 | 4 | 1 | 0.438 | |
| 20 | 8 | 3 | 5 | 0 | 0.375 | |
| 21 | 8 | 3 | 5 | 0 | 0.375 | |
| 22 | 8 | 3 | 5 | 0 | 0.375 | |
| 23 | 9 | 3 | 6 | 0 | 0.333 | |
| 24 | 9 | 3 | 6 | 0 | 0.333 | |
| 25 | 7 | 2 | 5 | 0 | 0.286 | |
| 26 | 8 | 2 | 6 | 0 | 0.25 | |
| 27 | 8 | 2 | 6 | 0 | 0.25 | |
| 28 | 9 | 2 | 7 | 0 | 0.222 | |
| 29 | 9 | 2 | 7 | 0 | 0.222 | |
| 30 | 8 | 1 | 7 | 0 | 0.125 | |
| 31 | 9 | 1 | 8 | 0 | 0.111 | |
| 32 | 9 | 1 | 8 | 0 | 0.111 |