Indianapolis Colts vs San Francisco 49ers: Prediction, Head-to-Head, Odds & Stats (Tue, 23 Dec '25)
Wojtek Kolan
Published on 23 Dec, 01:15 AM UTC
Next Match 23/12/25 at 01:15 AM
Indianapolis Colts vs San Francisco 49ers
📍 Lucas Oil Stadium, USA.
Scheduled H2H Match For Indianapolis Colts Vs San Francisco 49ers
NFL
Tue, 23 Dec 2025 at 01:15 AM UTC
Indianapolis Colts
USA
Recent Form
W
L
W
W
W
3
Win
Last 4 Played
4
0 Draws1
Win
1
Position
4
Shane Steichen
Manager
Kyle Shanahan
San Francisco 49ers
USA
Recent Form
W
L
W
L
W
3
Win
Last 4 Played
4
0 Draws1
Win
1
Position
4
Shane Steichen
Manager
Kyle Shanahan
Game Schedule - Time Of Fixture
Indianapolis Colts will square off vs San Francisco 49ers in NFL on Tue, 23 Dec 2025 at 01:15 AM UTC. Let’s investigate historical performances, recent stats and head-2-head information to find out the most accurate picks and best bets.
Indianapolis Colts vs San Francisco 49ers H2H Stats
Over the last 4 head-2-head fixtures between these competitors, Indianapolis Colts have won 3 times and San Francisco 49ers have got the victory on 1 occasion. In the most recent game between them, Indianapolis Colts won 18-30.
| Head-to-Head (Last 4 Matches) | |
|---|---|
| Indianapolis Colts | 3 |
| San Francisco 49ers | 1 |
Indianapolis Colts vs San Francisco 49ers Past H2H Matches
NFL
12:20 AM
25/10/21
25/10/21
San Francisco 49ers
18
Indianapolis Colts
30
05:00 PM
08/10/17
08/10/17
Indianapolis Colts
26
San Francisco 49ers
23
06:00 PM
25/11/01
25/11/01
Indianapolis Colts
21
San Francisco 49ers
40
NFL Preseason
08:30 PM
25/08/18
25/08/18
Indianapolis Colts
23
San Francisco 49ers
17
Indianapolis Colts Recent Matches
NFL (24 Matches)
08:05 PM
19/10/25
19/10/25
Los Angeles Chargers
24
Indianapolis Colts
38
W
05:00 PM
12/10/25
12/10/25
Indianapolis Colts
31
Arizona Cardinals
27
W
05:00 PM
05/10/25
05/10/25
Indianapolis Colts
40
Las Vegas Raiders
6
W
08:05 PM
28/09/25
28/09/25
Los Angeles Rams
27
Indianapolis Colts
20
L
05:00 PM
21/09/25
21/09/25
Tennessee Titans
20
Indianapolis Colts
41
W
08:05 PM
14/09/25
14/09/25
Indianapolis Colts
29
Denver Broncos
28
W
05:00 PM
07/09/25
07/09/25
Indianapolis Colts
33
Miami Dolphins
8
W
06:00 PM
05/01/25
05/01/25
Indianapolis Colts
26
Jacksonville Jaguars
23
W
06:00 PM
29/12/24
29/12/24
New York Giants
45
Indianapolis Colts
33
L
06:00 PM
22/12/24
22/12/24
Indianapolis Colts
38
Tennessee Titans
30
W
09:25 PM
15/12/24
15/12/24
Denver Broncos
31
Indianapolis Colts
13
L
06:00 PM
01/12/24
01/12/24
New England Patriots
24
Indianapolis Colts
25
W
06:00 PM
24/11/24
24/11/24
Indianapolis Colts
6
Detroit Lions
24
L
06:00 PM
17/11/24
17/11/24
New York Jets
27
Indianapolis Colts
28
W
06:00 PM
10/11/24
10/11/24
Indianapolis Colts
20
Buffalo Bills
30
L
01:20 AM
04/11/24
04/11/24
Minnesota Vikings
21
Indianapolis Colts
13
L
05:00 PM
27/10/24
27/10/24
Houston Texans
23
Indianapolis Colts
20
L
05:00 PM
20/10/24
20/10/24
Indianapolis Colts
16
Miami Dolphins
10
W
05:00 PM
13/10/24
13/10/24
Tennessee Titans
17
Indianapolis Colts
20
W
05:00 PM
06/10/24
06/10/24
Jacksonville Jaguars
37
Indianapolis Colts
34
L
05:00 PM
29/09/24
29/09/24
Indianapolis Colts
27
Pittsburgh Steelers
24
W
05:00 PM
22/09/24
22/09/24
Indianapolis Colts
21
Chicago Bears
16
W
05:00 PM
15/09/24
15/09/24
Green Bay Packers
16
Indianapolis Colts
10
L
05:00 PM
08/09/24
08/09/24
Indianapolis Colts
27
Houston Texans
29
L
NFL Preseason (6 Matches)
05:00 PM
23/08/25
23/08/25
Cincinnati Bengals
14
Indianapolis Colts
41
W
05:00 PM
16/08/25
16/08/25
Indianapolis Colts
19
Green Bay Packers
23
L
11:00 PM
07/08/25
07/08/25
Baltimore Ravens
24
Indianapolis Colts
16
L
12:00 AM
23/08/24
23/08/24
Cincinnati Bengals
14
Indianapolis Colts
27
W
11:00 PM
17/08/24
17/08/24
Indianapolis Colts
21
Arizona Cardinals
13
W
05:00 PM
11/08/24
11/08/24
Indianapolis Colts
30
Denver Broncos
34
L
San Francisco 49ers Recent Matches
NFL (24 Matches)
12:20 AM
20/10/25
20/10/25
San Francisco 49ers
20
Atlanta Falcons
10
W
08:25 PM
12/10/25
12/10/25
Tampa Bay Buccaneers
30
San Francisco 49ers
19
L
12:15 AM
03/10/25
03/10/25
Los Angeles Rams
23
San Francisco 49ers
26
W
08:05 PM
28/09/25
28/09/25
San Francisco 49ers
21
Jacksonville Jaguars
26
L
08:25 PM
21/09/25
21/09/25
San Francisco 49ers
16
Arizona Cardinals
15
W
05:00 PM
14/09/25
14/09/25
New Orleans Saints
21
San Francisco 49ers
26
W
08:05 PM
07/09/25
07/09/25
Seattle Seahawks
13
San Francisco 49ers
17
W
09:25 PM
05/01/25
05/01/25
Arizona Cardinals
47
San Francisco 49ers
24
L
01:15 AM
31/12/24
31/12/24
San Francisco 49ers
34
Detroit Lions
40
L
09:25 PM
22/12/24
22/12/24
Miami Dolphins
29
San Francisco 49ers
17
L
01:15 AM
13/12/24
13/12/24
San Francisco 49ers
6
Los Angeles Rams
12
L
09:25 PM
08/12/24
08/12/24
San Francisco 49ers
38
Chicago Bears
13
W
01:20 AM
02/12/24
02/12/24
Buffalo Bills
35
San Francisco 49ers
10
L
09:25 PM
24/11/24
24/11/24
Green Bay Packers
38
San Francisco 49ers
10
L
09:05 PM
17/11/24
17/11/24
San Francisco 49ers
17
Seattle Seahawks
20
L
06:00 PM
10/11/24
10/11/24
Tampa Bay Buccaneers
20
San Francisco 49ers
23
W
12:20 AM
28/10/24
28/10/24
San Francisco 49ers
30
Dallas Cowboys
24
W
08:25 PM
20/10/24
20/10/24
San Francisco 49ers
18
Kansas City Chiefs
28
L
12:15 AM
11/10/24
11/10/24
Seattle Seahawks
24
San Francisco 49ers
36
W
08:05 PM
06/10/24
06/10/24
San Francisco 49ers
23
Arizona Cardinals
24
L
08:05 PM
29/09/24
29/09/24
San Francisco 49ers
30
New England Patriots
13
W
08:25 PM
22/09/24
22/09/24
Los Angeles Rams
27
San Francisco 49ers
24
L
05:00 PM
15/09/24
15/09/24
Minnesota Vikings
23
San Francisco 49ers
17
L
12:15 AM
10/09/24
10/09/24
San Francisco 49ers
32
New York Jets
19
W
NFL Preseason (6 Matches)
12:30 AM
24/08/25
24/08/25
San Francisco 49ers
30
Los Angeles Chargers
23
W
08:00 PM
16/08/25
16/08/25
Las Vegas Raiders
19
San Francisco 49ers
22
W
12:30 AM
10/08/25
10/08/25
San Francisco 49ers
9
Denver Broncos
30
L
02:00 AM
24/08/24
24/08/24
Las Vegas Raiders
24
San Francisco 49ers
24
D
12:00 AM
19/08/24
19/08/24
San Francisco 49ers
16
New Orleans Saints
10
W
11:00 PM
10/08/24
10/08/24
Tennessee Titans
17
San Francisco 49ers
13
L
Indianapolis Colts Next Fixtures
NFL
08:25 PM
26/10/25
26/10/25
Indianapolis Colts
Tennessee Titans
Prediction
06:00 PM
02/11/25
02/11/25
Pittsburgh Steelers
Indianapolis Colts
Prediction
02:30 PM
09/11/25
09/11/25
Indianapolis Colts
Atlanta Falcons
Prediction
06:00 PM
23/11/25
23/11/25
Kansas City Chiefs
Indianapolis Colts
Prediction
06:00 PM
30/11/25
30/11/25
Indianapolis Colts
Houston Texans
Prediction
06:00 PM
07/12/25
07/12/25
Jacksonville Jaguars
Indianapolis Colts
Prediction
09:25 PM
14/12/25
14/12/25
Seattle Seahawks
Indianapolis Colts
Prediction
01:15 AM
23/12/25
23/12/25
Indianapolis Colts
San Francisco 49ers
Prediction
06:00 PM
28/12/25
28/12/25
Indianapolis Colts
Jacksonville Jaguars
Prediction
06:00 PM
04/01/26
04/01/26
Houston Texans
Indianapolis Colts
Prediction
San Francisco 49ers Next Fixtures
NFL
05:00 PM
26/10/25
26/10/25
Houston Texans
San Francisco 49ers
Prediction
06:00 PM
02/11/25
02/11/25
New York Giants
San Francisco 49ers
Prediction
09:25 PM
09/11/25
09/11/25
San Francisco 49ers
Los Angeles Rams
Prediction
09:05 PM
16/11/25
16/11/25
Arizona Cardinals
San Francisco 49ers
Prediction
01:15 AM
25/11/25
25/11/25
San Francisco 49ers
Carolina Panthers
Prediction
06:00 PM
30/11/25
30/11/25
Cleveland Browns
San Francisco 49ers
Prediction
09:25 PM
14/12/25
14/12/25
San Francisco 49ers
Tennessee Titans
Prediction
01:15 AM
23/12/25
23/12/25
Indianapolis Colts
San Francisco 49ers
Prediction
01:20 AM
29/12/25
29/12/25
San Francisco 49ers
Chicago Bears
Prediction
06:00 PM
04/01/26
04/01/26
San Francisco 49ers
Seattle Seahawks
Prediction
Indianapolis Colts Last Match Played stats
Los Angeles Chargers vs Indianapolis Colts
Final Score :24 - 38
| (H) | Offense | (A) |
|---|---|---|
| 3 | Touchdowns | 5 |
| 1/1 | Field goals | 1/1 |
| 445 | Total yards | 401 |
| 2 | Turnovers | 0 |
| 3/4 | Red zone efficiency | 4/5 |
| 34:27 | Time of Possession | 25:33 |
| 25 | First downs | 24 |
| 1 | First downs by penalty | 2 |
| 8/16 (50%) | Third down efficiency | 5/11 (45%) |
| 1 | Punts | 2 |
| 53 | Average yards per punt | 43.5 |
| 6 | Average yards per play | 6.9 |
| (H) | Passing | (A) |
| 19 | First downs by passing | 14 |
| 391 | Net yards passing | 281 |
| 420 | Gross yards passing | 288 |
| 3 | Passing touchdowns | 2 |
| 2 | Interceptions thrown | 0 |
| 6.7 | Average passing yards per attempt | 8 |
| 10 | Red zone passing attempts | 7 |
| (H) | Rushing | (A) |
| 16 | Rushing attempts | 23 |
| 54 | Rushing yards | 120 |
| 3.4 | Average rushing yards per attempt | 5.2 |
| 4 | First downs by rushing | 9 |
| 5 | Red zone rushing attempts | 5 |
| (H) | Other | (A) |
| 6 | Penalties | 3 |
| 35 | Yards penalized | 42 |
| 0 | Fumbles | 1 |
| 0 | Fumbles lost | 0 |
San Francisco 49ers Last Match Played stats
San Francisco 49ers vs Atlanta Falcons
Final Score :20 - 10
| (H) | Offense | (A) |
|---|---|---|
| 2 | Touchdowns | 1 |
| 2/2 | Field goals | 1/1 |
| 324 | Total yards | 292 |
| 1 | Turnovers | 1 |
| 2/2 | Red zone efficiency | 1/2 |
| 32:10 | Time of Possession | 27:50 |
| 23 | First downs | 19 |
| 3 | First downs by penalty | 1 |
| 9/15 (60%) | Third down efficiency | 5/11 (45%) |
| 3 | Punts | 3 |
| 47.7 | Average yards per punt | 50.7 |
| 4.9 | Average yards per play | 4.9 |
| (H) | Passing | (A) |
| 10 | First downs by passing | 13 |
| 150 | Net yards passing | 230 |
| 152 | Gross yards passing | 241 |
| 0 | Passing touchdowns | 1 |
| 1 | Interceptions thrown | 0 |
| 5.6 | Average passing yards per attempt | 5.8 |
| 1 | Red zone passing attempts | 1 |
| (H) | Rushing | (A) |
| 39 | Rushing attempts | 20 |
| 174 | Rushing yards | 62 |
| 4.5 | Average rushing yards per attempt | 3.1 |
| 12 | First downs by rushing | 3 |
| 4 | Red zone rushing attempts | 2 |
| (H) | Other | (A) |
| 3 | Penalties | 6 |
| 25 | Yards penalized | 43 |
| 0 | Fumbles | 1 |
| 0 | Fumbles lost | 1 |
NFL 25/26 Standings
| POS | TEAM | MP | W | L | D | PTS |
|---|---|---|---|---|---|---|
| 1 | 7 | 6 | 1 | 0 | 0.857 | |
| 2 | 6 | 4 | 1 | 1 | 0.75 | |
| 3 | 7 | 5 | 2 | 0 | 0.714 | |
| 4 | 7 | 5 | 2 | 0 | 0.714 | |
| 5 | 7 | 5 | 2 | 0 | 0.714 | |
| 6 | 7 | 5 | 2 | 0 | 0.714 | |
| 7 | 7 | 5 | 2 | 0 | 0.714 | |
| 8 | 7 | 5 | 2 | 0 | 0.714 | |
| 9 | 7 | 5 | 2 | 0 | 0.714 | |
| 10 | 7 | 5 | 2 | 0 | 0.714 | |
| 11 | 6 | 4 | 2 | 0 | 0.667 | |
| 12 | 6 | 4 | 2 | 0 | 0.667 | |
| 13 | 6 | 4 | 2 | 0 | 0.667 | |
| 14 | 7 | 4 | 3 | 0 | 0.571 | |
| 15 | 7 | 4 | 3 | 0 | 0.571 | |
| 16 | 7 | 4 | 3 | 0 | 0.571 | |
| 17 | 7 | 4 | 3 | 0 | 0.571 | |
| 18 | 6 | 3 | 3 | 0 | 0.5 | |
| 19 | 6 | 3 | 3 | 0 | 0.5 | |
| 20 | 7 | 3 | 3 | 1 | 0.5 | |
| 21 | 7 | 3 | 4 | 0 | 0.429 | |
| 22 | 7 | 3 | 4 | 0 | 0.429 | |
| 23 | 6 | 2 | 4 | 0 | 0.333 | |
| 24 | 7 | 2 | 5 | 0 | 0.286 | |
| 25 | 7 | 2 | 5 | 0 | 0.286 | |
| 26 | 7 | 2 | 5 | 0 | 0.286 | |
| 27 | 7 | 2 | 5 | 0 | 0.286 | |
| 28 | 6 | 1 | 5 | 0 | 0.167 | |
| 29 | 7 | 1 | 6 | 0 | 0.143 | |
| 30 | 7 | 1 | 6 | 0 | 0.143 | |
| 31 | 7 | 1 | 6 | 0 | 0.143 | |
| 32 | 7 | 0 | 7 | 0 | 0 |