Indianapolis Colts vs San Francisco 49ers: Prediction, Head-to-Head, Odds & Stats (Tue, 23 Dec '25)

    Wojtek Kolan

    Wojtek Kolan

    Published on 23 Dec, 01:15 AM

    Next Match 23/12/25 at 01:15 AM UTC

    Indianapolis Colts vs San Francisco 49ers
    📍 Lucas Oil Stadium, USA.

    Scheduled H2H Match For Indianapolis Colts Vs San Francisco 49ers

    NFL

    Tue, 23 Dec 2025 at 01:15 AM UTC

    Indianapolis Colts
    Indianapolis Colts

    USA USA

    Recent Form

    W
    W
    L
    W
    L
    San Francisco 49ers
    San Francisco 49ers

    USA USA

    Recent Form

    L
    W
    L
    W
    W

    3

    Win

    Last 4 Played

    4
    0 Draws

    1

    Win

    6
    Position
    9
    Shane Steichen
    Manager
    Kyle Shanahan

    Game Schedule - Time Of Fixture

    Indianapolis Colts will square off vs San Francisco 49ers in NFL on Tue, 23 Dec 2025 at 01:15 AM UTC. Let’s investigate historical performances, recent stats and head-2-head information to find out the most accurate picks and best bets.

    Indianapolis Colts vs San Francisco 49ers H2H Stats

    Over the most recent 4 head-2-head games for these rivals, Indianapolis Colts have got the victory 3 times and San Francisco 49ers have got the victory on 1 occasion. In the most recent fixture between them, Indianapolis Colts won 18-30.


    Head-to-Head (Last 4 Matches)
    Indianapolis Colts3
    San Francisco 49ers1

    Indianapolis Colts vs San Francisco 49ers Past H2H Matches

    9464
    NFL
    12:20 AM
    25/10/21
    San Francisco 49ers
    18
    Indianapolis Colts
    30
    05:00 PM
    08/10/17
    Indianapolis Colts
    26
    San Francisco 49ers
    23
    06:00 PM
    25/11/01
    Indianapolis Colts
    21
    San Francisco 49ers
    40
    9465
    NFL Preseason
    08:30 PM
    25/08/18
    Indianapolis Colts
    23
    San Francisco 49ers
    17

    Indianapolis Colts Recent Matches

    9464
    NFL (27 Matches)
    06:00 PM
    23/11/25
    Kansas City Chiefs
    23
    Indianapolis Colts
    20
    L
    02:30 PM
    09/11/25
    Indianapolis Colts
    31
    Atlanta Falcons
    25
    W
    06:00 PM
    02/11/25
    Pittsburgh Steelers
    27
    Indianapolis Colts
    20
    L
    08:25 PM
    26/10/25
    Indianapolis Colts
    38
    Tennessee Titans
    14
    W
    08:05 PM
    19/10/25
    Los Angeles Chargers
    24
    Indianapolis Colts
    38
    W
    05:00 PM
    12/10/25
    Indianapolis Colts
    31
    Arizona Cardinals
    27
    W
    05:00 PM
    05/10/25
    Indianapolis Colts
    40
    Las Vegas Raiders
    6
    W
    08:05 PM
    28/09/25
    Los Angeles Rams
    27
    Indianapolis Colts
    20
    L
    05:00 PM
    21/09/25
    Tennessee Titans
    20
    Indianapolis Colts
    41
    W
    08:05 PM
    14/09/25
    Indianapolis Colts
    29
    Denver Broncos
    28
    W
    05:00 PM
    07/09/25
    Indianapolis Colts
    33
    Miami Dolphins
    8
    W
    06:00 PM
    05/01/25
    Indianapolis Colts
    26
    Jacksonville Jaguars
    23
    W
    06:00 PM
    29/12/24
    New York Giants
    45
    Indianapolis Colts
    33
    L
    06:00 PM
    22/12/24
    Indianapolis Colts
    38
    Tennessee Titans
    30
    W
    09:25 PM
    15/12/24
    Denver Broncos
    31
    Indianapolis Colts
    13
    L
    06:00 PM
    01/12/24
    New England Patriots
    24
    Indianapolis Colts
    25
    W
    06:00 PM
    24/11/24
    Indianapolis Colts
    6
    Detroit Lions
    24
    L
    06:00 PM
    17/11/24
    New York Jets
    27
    Indianapolis Colts
    28
    W
    06:00 PM
    10/11/24
    Indianapolis Colts
    20
    Buffalo Bills
    30
    L
    01:20 AM
    04/11/24
    Minnesota Vikings
    21
    Indianapolis Colts
    13
    L
    05:00 PM
    27/10/24
    Houston Texans
    23
    Indianapolis Colts
    20
    L
    05:00 PM
    20/10/24
    Indianapolis Colts
    16
    Miami Dolphins
    10
    W
    05:00 PM
    13/10/24
    Tennessee Titans
    17
    Indianapolis Colts
    20
    W
    05:00 PM
    06/10/24
    Jacksonville Jaguars
    37
    Indianapolis Colts
    34
    L
    05:00 PM
    29/09/24
    Indianapolis Colts
    27
    Pittsburgh Steelers
    24
    W
    05:00 PM
    22/09/24
    Indianapolis Colts
    21
    Chicago Bears
    16
    W
    05:00 PM
    15/09/24
    Green Bay Packers
    16
    Indianapolis Colts
    10
    L
    9465
    NFL Preseason (3 Matches)
    05:00 PM
    23/08/25
    Cincinnati Bengals
    14
    Indianapolis Colts
    41
    W
    05:00 PM
    16/08/25
    Indianapolis Colts
    19
    Green Bay Packers
    23
    L
    11:00 PM
    07/08/25
    Baltimore Ravens
    24
    Indianapolis Colts
    16
    L

    San Francisco 49ers Recent Matches

    9464
    NFL (27 Matches)
    01:15 AM
    25/11/25
    San Francisco 49ers
    20
    Carolina Panthers
    9
    W
    09:05 PM
    16/11/25
    Arizona Cardinals
    22
    San Francisco 49ers
    41
    W
    09:25 PM
    09/11/25
    San Francisco 49ers
    26
    Los Angeles Rams
    42
    L
    06:00 PM
    02/11/25
    New York Giants
    24
    San Francisco 49ers
    34
    W
    05:00 PM
    26/10/25
    Houston Texans
    26
    San Francisco 49ers
    15
    L
    12:20 AM
    20/10/25
    San Francisco 49ers
    20
    Atlanta Falcons
    10
    W
    08:25 PM
    12/10/25
    Tampa Bay Buccaneers
    30
    San Francisco 49ers
    19
    L
    12:15 AM
    03/10/25
    Los Angeles Rams
    23
    San Francisco 49ers
    26
    W
    08:05 PM
    28/09/25
    San Francisco 49ers
    21
    Jacksonville Jaguars
    26
    L
    08:25 PM
    21/09/25
    San Francisco 49ers
    16
    Arizona Cardinals
    15
    W
    05:00 PM
    14/09/25
    New Orleans Saints
    21
    San Francisco 49ers
    26
    W
    08:05 PM
    07/09/25
    Seattle Seahawks
    13
    San Francisco 49ers
    17
    W
    09:25 PM
    05/01/25
    Arizona Cardinals
    47
    San Francisco 49ers
    24
    L
    01:15 AM
    31/12/24
    San Francisco 49ers
    34
    Detroit Lions
    40
    L
    09:25 PM
    22/12/24
    Miami Dolphins
    29
    San Francisco 49ers
    17
    L
    01:15 AM
    13/12/24
    San Francisco 49ers
    6
    Los Angeles Rams
    12
    L
    09:25 PM
    08/12/24
    San Francisco 49ers
    38
    Chicago Bears
    13
    W
    01:20 AM
    02/12/24
    Buffalo Bills
    35
    San Francisco 49ers
    10
    L
    09:25 PM
    24/11/24
    Green Bay Packers
    38
    San Francisco 49ers
    10
    L
    09:05 PM
    17/11/24
    San Francisco 49ers
    17
    Seattle Seahawks
    20
    L
    06:00 PM
    10/11/24
    Tampa Bay Buccaneers
    20
    San Francisco 49ers
    23
    W
    12:20 AM
    28/10/24
    San Francisco 49ers
    30
    Dallas Cowboys
    24
    W
    08:25 PM
    20/10/24
    San Francisco 49ers
    18
    Kansas City Chiefs
    28
    L
    12:15 AM
    11/10/24
    Seattle Seahawks
    24
    San Francisco 49ers
    36
    W
    08:05 PM
    06/10/24
    San Francisco 49ers
    23
    Arizona Cardinals
    24
    L
    08:05 PM
    29/09/24
    San Francisco 49ers
    30
    New England Patriots
    13
    W
    08:25 PM
    22/09/24
    Los Angeles Rams
    27
    San Francisco 49ers
    24
    L
    9465
    NFL Preseason (3 Matches)
    12:30 AM
    24/08/25
    San Francisco 49ers
    30
    Los Angeles Chargers
    23
    W
    08:00 PM
    16/08/25
    Las Vegas Raiders
    19
    San Francisco 49ers
    22
    W
    12:30 AM
    10/08/25
    San Francisco 49ers
    9
    Denver Broncos
    30
    L

    Indianapolis Colts Next Fixtures

    San Francisco 49ers Next Fixtures

    Indianapolis Colts Last Match Played stats

    Kansas City Chiefs vs Indianapolis Colts

    Final Score :23 - 20

    (H)Offense (A)
    1Touchdowns2
    5/5Field goals2/2
    494Total yards255
    2Turnovers0
    1/6Red zone efficiency2/4
    42:35Time of Possession25:28
    33First downs10
    0First downs by penalty5
    7/16 (43%)Third down efficiency5/13 (38%)
    3Punts6
    49Average yards per punt49
    5.4Average yards per play5.1
    (H)Passing (A)
    15First downs by passing6
    346Net yards passing181
    352Gross yards passing181
    0Passing touchdowns2
    1Interceptions thrown0
    6.9Average passing yards per attempt5.8
    11Red zone passing attempts6
    (H)Rushing (A)
    41Rushing attempts19
    148Rushing yards74
    3.6Average rushing yards per attempt3.9
    13First downs by rushing4
    9Red zone rushing attempts3
    (H)Other (A)
    7Penalties11
    57Yards penalized83
    1Fumbles0
    1Fumbles lost0

    San Francisco 49ers Last Match Played stats

    San Francisco 49ers vs Carolina Panthers

    Final Score :20 - 9

    (H)Offense (A)
    2Touchdowns1
    2/2Field goals1/2
    340Total yards230
    3Turnovers2
    2/3Red zone efficiency0/2
    37:42Time of Possession22:18
    23First downs12
    0First downs by penalty0
    7/13 (53%)Third down efficiency1/7 (14%)
    1Punts4
    40Average yards per punt50.3
    4.9Average yards per play5.3
    (H)Passing (A)
    11First downs by passing9
    193Net yards passing161
    193Gross yards passing169
    1Passing touchdowns1
    3Interceptions thrown2
    6Average passing yards per attempt5.4
    1Red zone passing attempts3
    (H)Rushing (A)
    38Rushing attempts13
    147Rushing yards69
    3.9Average rushing yards per attempt5.3
    12First downs by rushing3
    7Red zone rushing attempts5
    (H)Other (A)
    2Penalties4
    6Yards penalized30
    1Fumbles1
    0Fumbles lost0

    NFL 25/26 Standings

    POSTEAMMPWLDPTS
    1New England Patriots1210200.833
    2Denver Broncos119200.818
    3Los Angeles Rams119200.818
    4Chicago Bears129300.75
    5Seattle Seahawks118300.727
    6Indianapolis Colts118300.727
    7Green Bay Packers128310.708
    8Philadelphia Eagles128400.667
    9San Francisco 49ers128400.667
    10Jacksonville Jaguars117400.636
    11Los Angeles Chargers117400.636
    12Buffalo Bills117400.636
    13Detroit Lions127500.583
    14Houston Texans116500.545
    15Pittsburgh Steelers116500.545
    16Tampa Bay Buccaneers116500.545
    17Dallas Cowboys126510.542
    18Carolina Panthers126600.5
    19Kansas City Chiefs126600.5
    20Baltimore Ravens126600.5
    21Minnesota Vikings114700.364
    22Atlanta Falcons114700.364
    23Miami Dolphins114700.364
    24Cincinnati Bengals124800.333
    25Cleveland Browns113800.273
    26Arizona Cardinals113800.273
    27Washington Commanders113800.273
    28Las Vegas Raiders112900.182
    29New Orleans Saints112900.182
    30New York Jets112900.182
    31New York Giants1221000.167
    32Tennessee Titans1111000.091

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